So here's my take - worthy road trip if you could do it. With that I'd leave out the southern ones. I'm personally not crazy about Cigar City, Cycle and Sweetwater beers. That would cut out allot of miles!
Also, there's a bunch of hyped breweries in this list and probably some just as good that you could hot up. One comes to mind - Barrelhouse Brewing in Paso Robles, CA. Awesome beer!
EDIT - no Firestone Walker on this list!